PXE Awareness

Volume 19, Issue 1 June 2013


Elastic Fibre Damage Induced

by Low-Dose D-Penicillamine

click to listen ( 479KB AUDIO SIZE )

We have studied 23 patients receiving penicillamine for the treatment of rheumatoid arthritis to determine the prevalence of penicillamine-induced elastosis. One female patient had pseudoxanthoma elasticum-like skin changes and bramble-bush elastosis without calcification in the involved skin. Penicillamine elastosis was present in the joint capsule in 62% of eight patients or 64% of II joints examined and was detected in joint capsules after as little as I year of treatment.